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Product Name:- Symoclav-Duo Dry syrup
Each 5mL of Symoclav-Duo Dry syrup consists of Amoxicillin trihydrate(equivalent to amoxicillin) 400mg and diluted potassium clavulanate IP(equivalent to clavulanic acid) 57mg.
Symoclav-Duo Dry syrup is a potent antibiotic combination of amoxicillinand clavulanic acid. Amoxicillin is a beta-lactam antibiotic withbroad-spectrum activity, while clavulanic acid is a beta-lactamase inhibitorwhose prime function is to prevent the enzymatic degradation of amoxicillin bybeta-lactamases present in the bacterial cell wall.
Like other beta-lactam antibiotics, amoxicillin works by inhibiting thecell wall synthesis in bacteria. Amoxicillin interferes with thetranspeptidation step, which is the last step of peptidoglycan synthesis andprevents the cross-linking reaction. This cross-linking is crucial for themaintenance of cellular integrity in bacteria. Lack of cross-linkage in thecell wall increases the permeability and eventually leads to the death of thebacterial cells.
Clavulanic acid's role in this combination is to protect the antibioticactivity of amoxicillin. Amoxicillin is highly susceptible to beta-lactamasesand cephalosporinases activity; thus, it has to be administered in combinationwith clavulanic acid, which will bind to the beta-lactamases and letamoxicillin perform its activity.