Diclofenac Potassium 50 mg + Serratiopeptidase 10 mg tablet

Product Description

DICLOFENAC POTASSIUM 50MG +SERRATIOPEPTIDASE 10MG TABLETDiclofenac Potassium is a non-steroidal anti-inflammatory agent (NSAIDs) with antipyretic and analgesic actions.Serratiopeptidase is a proteolytic enzyme (protease) produced by enterobacterium Serratia sp. E-15 used in the prevention of pain and swelling.Indications and Usage: ? For the treatment of primary dysmenorrhea.? For the treatment of mild to moderate pain.? For the relief from the signs and symptoms of osteoarthritis.? For the relief from the signs and symptoms of rheumatoid arthritis.? Chronic inflammation.? Headaches, muscle and joint pain.? Serious diseases like cancer and heart disease.? Superficial thrombophlebitis.? Postoperative & traumatic swelling.? Acute or chronic ear, nose or throat disorder.Rationale of Combination: Product Description: Diclofenac Potassium is used as an anti-inflammatory agent to pacify mild to moderate pain and inflammation. Common conditions associated with pain andinflammation include arthritis, trauma, surgery and fibermyalgia. Additionally, serratiopeptidase helps to reduce fluid retention in affected areas, whichcontributes to proper drainage and a quicker recovery.Pharmacology: Diclofenac Potassium: Diclofenac Potassium is an acetic acid non-steroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties. Diclofenac Potassium inhibits theproduction of prostaglandins by inhibiting pathways thereby exhibiting anti- inflammatory effects.Pharmacokinetic: Absorption: Well absorbed following oral administration.Distribution: widely distributed in animals. Plasma protein binding exhibited is >99%.Elimination: hepatic metabolism leads to elimination through urine.Serratiopeptidase: Serratiopeptidase is an enzyme isolated from a non-pathogenic bacteria called enterobacteria Serratia E15. Serratiopeptidase has powerful anti-inflammatoryproperties and is particularly useful for post-traumatic swelling, fibrocystic breast disease and bronchitis. It is able to digest dead tissue, blood clots, cysts, andarterial plaques.Pharmacokinetic: Absorption: On oral administration, serratiopeptidase is absorbed in GI tract.Distribution: Distributed throughout the body tissues, unchanged via systemic circulation. It reaches in higher concentration in inflamed tissues.Serratiopeptidase levels in inflammatory exudates rises gradually with decline in blood levels indicating that serratiopeptidase is quite rapidly transferred to thesite of inflammation.Adverse Effects: ? Skin rash? Diarrhea? Gastrointestinal disturbance? Noseblee? DizzinessContraindications: Diclofenac sodium + Serratiopeptidase is contraindicated in patients with active GI bleeding or perforations, asthma, renal or hepatic disorders, hypertension,porphyria, peri-operative pain in CABG surgery patients and bleeding disorders.Drug Interactions: Diclofenac potassium+ Serratiopeptidase should not be taken concomitantly with other NSAIDs, anticoagulants including low-dose/LMW heparin, sucralfate,triamterene, cyclosporine, cholestyramine, colestipol, digoxin, methotrexate and lithium.Other Interactions: Diclofenac potassium + Serratiopeptidase should be taken with food. Take the drug immediately after meals to avoid GI disturbances.StorageStore at 15-30C.