Telmisartan and Hydrochlorothiazide Tablets is a newer type of blood pressure medicine known as an angiotensin II receptor blocker (ARB for short). As the name implies, telmisartan blocks angiotensin II receptors. This decreases the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict). By blocking the effects of angiotensin II, telmisartan causes blood vessels to relax.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water that the kidneys remove from the blood. This extra salt and water are passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide causes a decrease in blood volume.
Telmisartan and Hydrochlorothiazide Tablets should be used in people whose blood pressure cannot be controlled with telmisartan alone. Before switching to the fixed dosage combination, individual dose titration with each of the two components is suggested. Direct conversion from monotherapy to fixed combination treatment may be undertaken when clinically indicated.
The dose should not exceed 40 mg/12.5 mg Telmisartan/Hydrochlorothiazide once a day in individuals with mild to severe hepatic impairment. People with severe hepatic impairment should not take this tablets. In individuals with poor hepatic function, this should be taken with caution.