Pregabalin With Methylcobalamin Capsules

Indications and Usage:
? It is used for neuropathic pain associated with spinal cord injury.
? Diabetic peripheral neuropathy.
? Treatment of fibromyalgia.
? It is also used for treatment of chronic pain, perioperative pain, and migraine.
? Supports the nervous system
? Helps memory and learning
? Boosts energy
? Helps control homocysteine levels
? Promotes a healthy cardiovascular system
? Enhances immune system function
? Effectively supports brain and nerve function.
Drug Interactions:
BEFORE TAKING THIS MEDICINE TELL THE DOCTOR ABOUT ANY MEDICAL PROBLEMS AN ALLERGIES THAT PATIENT HAS NOW OR HAS HAD.
Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the
health expert about intake of any other medications including non-prescription medications.
Mechanism of action:
Combination of Pregabalin and Methylcobalamin not only decreases the release of neurotransmitters but also helps in regeneration of the myelin sheath.
Pregabalin also has got analgesic activity which reduces the pain associated with neuropathy. Thus the combination of Pregabalin and Methylcobalamin is useful for arresting the progress of diabetic neuropathy and also helps in relieving the pain associated with neuropathy. Methylcobalamin is a co-factor of methionine
synthase, an enzyme that transfers methyl groups to homocysteine to regenerate methionine. Elevated homocysteine levels are a risk factor for coronary artery
disease. Methionine can be transformed to S-adenoxylmethionine (SAM) that is involved in a variety of methylation reactions in the body, one of which is
alleviating depression.
Pharmacodynamics:
It binds to the ?2? (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system. It help to decreases the release of
neurotransmitters including glutamate, norepinephrine, substance P and calcitonin gene-related peptide. However, unlike anxiolytic compounds (e.g.,
 which exert their therapeutic effects through binding to GABA, . It neither binds directly to these receptors nor
augments GABA currents or affects GABA metabolism. The half life for pregabalin is 6.3 hours.