Telmisartan 40mg + Hydrochlorothiazide 12.5 mg Tablets

Telmisartan is a newer type of blood pressure medicine known as an angiotensin II receptor blocker (ARB for short). As the name implies, telmisartan blocks
angiotensin II receptors. This decreases the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict). By
blocking the effects of angiotensin II, telmisartan causes blood vessels to relax.
Hydrochlorothiazide is a diuretic, which is commonly referred to as a "water pill." It works by increasing the amount of salt and water that the kidneys remove
from the blood. This extra salt and water are passed out through the urine. By increasing the amount of water removed from the blood, hydrochlorothiazide
causes a decrease in blood volume.
Indications and Usage:
High Blood Pressure (Hypertension)
Drug Interaction:
? Complementry mechanism of action
? Reduction in peripheral resistence with ARB
? Reduction of fluid volume with Diuretics
? ARBs counteract reactive increase in blood pressure related to diuretic induced renin secretion
? ARBs ameliorates diuretic induced potassium depletion
? Well tolerated; fewer metabolic disturbances
? No significant variation in pharmacokinetic parameters of telmisartan in presence of hydrochlorothiazide
Combination of telmisartan with hydrochlorothiazide was found to be more effective than each agent alone in lowering blood pressure. Indeed , combining
telmisartan with hydrochlorothiazide enhances the antihypertensive efficacy of telmisartan in patients not adequately controlled with telmisartan alone.
Pharmacokinetic:
Telmisartan is orally well absorbed and metabolized to an active metabolite which is more potent than Losartan as AT1 antagonist. Orally administered
hydrochlorothiazide is rapidly absorbed and diuretic effect is seen in 1 hour and their duration lasts up to 12-24 hours. Both telmisartan and hydrochlorothiazide
has longer duration of actions. These agents are bound to plasma proteins to varying degrees and this has no correlation to their half-life.
Pharmacodynamics:
The pharmacodynamics of telmisartan & hydrochlorothiazide has been investigated in vitro and in vivo in rodents, guinea pigs, rabbits and dogs. The
combination of telmisartan with hydrochlorothiazide (40 mg/12.5 mg and 80 mg/12.5 mg) is expected to benefit patients with hypertension who are not
adequately responsive to telmisartan alone.
Contraindications:
? Second and third trimesters of pregnancy.
? Biliary obstructive disorders.
? Severe hepatic impairment.
Conclusion:
This is a new combination for a muscle relaxant and displays anti - inflammatory and analgesic properties. Thiocolchicoside & Diclofenac Sodium is well absorbed
from the gastrointestinal tract. It shows its effect in 1 - 2 hr after oral administration. This combination is used to treat various painful inflammatory conditions.
Diclofenac Sodium has an outstanding anti-inflammatory profile mediated primarily through inhibition of cyclooxygenase (COX) activity and suppression of PGE2
synthesis From the above discussion, it can be concluded that this medicine could improve the quality of life of patients with as well as muscle relaxant in
addition. Moreover it has a considerable safety profile, with persistent results.
Storage:
This medicinal product does not require any special temperature storage conditions. Store in the original package in order to protect from moisture.